Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2350207..2350902 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag O3Q54_RS10985 Protein ID WP_003410811.1
Coordinates 2350207..2350641 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag O3Q54_RS10990 Protein ID WP_003410814.1
Coordinates 2350648..2350902 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS10975 (O3Q54_10975) 2346441..2349402 + 2962 Protein_2170 DEAD/DEAH box helicase -
O3Q54_RS10980 (O3Q54_10980) 2349395..2350228 + 834 WP_003899172.1 SWIM zinc finger family protein -
O3Q54_RS10985 (O3Q54_10985) 2350207..2350641 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS10990 (O3Q54_10990) 2350648..2350902 - 255 WP_003410814.1 antitoxin Antitoxin
O3Q54_RS10995 (O3Q54_10995) 2350918..2351175 - 258 WP_003410816.1 hypothetical protein -
O3Q54_RS11000 (O3Q54_11000) 2352122..2352418 + 297 WP_003410820.1 PE family protein -
O3Q54_RS11005 (O3Q54_11005) 2352474..2353205 + 732 WP_003900467.1 PPE family protein -
O3Q54_RS11010 (O3Q54_11010) 2353745..2354491 - 747 WP_003906749.1 proteasome subunit alpha -
O3Q54_RS11015 (O3Q54_11015) 2354488..2355363 - 876 WP_003411023.1 proteasome subunit beta -
O3Q54_RS11020 (O3Q54_11020) 2355360..2355554 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T282201 WP_003410811.1 NZ_CP125620:c2350641-2350207 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT282201 WP_003410814.1 NZ_CP125620:c2350902-2350648 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References