Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2306967..2307603 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag O3Q54_RS10790 Protein ID WP_003410654.1
Coordinates 2307193..2307603 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag O3Q54_RS10785 Protein ID WP_003410651.1
Coordinates 2306967..2307200 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS10770 (O3Q54_10770) 2302415..2302816 + 402 WP_009937711.1 metal ABC transporter permease -
O3Q54_RS10775 (O3Q54_10775) 2302817..2303221 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
O3Q54_RS10780 (O3Q54_10780) 2303305..2306889 - 3585 WP_003410648.1 cobaltochelatase subunit CobN -
O3Q54_RS10785 (O3Q54_10785) 2306967..2307200 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
O3Q54_RS10790 (O3Q54_10790) 2307193..2307603 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
O3Q54_RS10795 (O3Q54_10795) 2307587..2308678 + 1092 WP_003900454.1 precorrin-3B synthase -
O3Q54_RS10800 (O3Q54_10800) 2308688..2309314 + 627 WP_003410658.1 precorrin-8X methylmutase -
O3Q54_RS10805 (O3Q54_10805) 2309311..2310837 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
O3Q54_RS10810 (O3Q54_10810) 2310783..2312006 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T282200 WP_003410654.1 NZ_CP125620:2307193-2307603 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT282200 WP_003410651.1 NZ_CP125620:2306967-2307200 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References