Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2206546..2207234 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag O3Q54_RS10330 Protein ID WP_003409958.1
Coordinates 2206546..2206965 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag O3Q54_RS10335 Protein ID WP_003409968.1
Coordinates 2206974..2207234 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS10310 (O3Q54_10310) 2202296..2202889 + 594 Protein_2037 class I SAM-dependent methyltransferase -
O3Q54_RS10315 (O3Q54_10315) 2202852..2204297 - 1446 WP_003899115.1 APC family permease -
O3Q54_RS10320 (O3Q54_10320) 2204476..2205162 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
O3Q54_RS10325 (O3Q54_10325) 2205353..2206321 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
O3Q54_RS10330 (O3Q54_10330) 2206546..2206965 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS10335 (O3Q54_10335) 2206974..2207234 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
O3Q54_RS10340 (O3Q54_10340) 2207377..2209053 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
O3Q54_RS10345 (O3Q54_10345) 2209041..2209694 - 654 WP_003409976.1 cutinase Cfp21 -
O3Q54_RS10350 (O3Q54_10350) 2209809..2210039 + 231 WP_003409980.1 DUF167 domain-containing protein -
O3Q54_RS10355 (O3Q54_10355) 2210124..2211035 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
O3Q54_RS10360 (O3Q54_10360) 2211144..2211743 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T282195 WP_003409958.1 NZ_CP125620:c2206965-2206546 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT282195 WP_003409968.1 NZ_CP125620:c2207234-2206974 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References