Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2174417..2175120 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag O3Q54_RS10110 Protein ID WP_003409778.1
Coordinates 2174417..2174746 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag O3Q54_RS10115 Protein ID WP_003409780.1
Coordinates 2174743..2175120 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS10090 (O3Q54_10090) 2170800..2171870 + 1071 WP_003899091.1 epoxide hydrolase EphB -
O3Q54_RS10095 (O3Q54_10095) 2171867..2172382 + 516 WP_003409718.1 flavin reductase family protein -
O3Q54_RS10100 (O3Q54_10100) 2172379..2173440 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
O3Q54_RS10105 (O3Q54_10105) 2173437..2174207 + 771 WP_003409775.1 SDR family oxidoreductase -
O3Q54_RS10110 (O3Q54_10110) 2174417..2174746 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
O3Q54_RS10115 (O3Q54_10115) 2174743..2175120 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
O3Q54_RS10120 (O3Q54_10120) 2175117..2175707 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
O3Q54_RS10125 (O3Q54_10125) 2175762..2177126 + 1365 WP_023642649.1 HNH endonuclease signature motif containing protein -
O3Q54_RS10130 (O3Q54_10130) 2177281..2177733 - 453 WP_003899095.1 lipoprotein -
O3Q54_RS10135 (O3Q54_10135) 2177797..2178198 + 402 WP_003409869.1 hypothetical protein -
O3Q54_RS10140 (O3Q54_10140) 2178191..2178373 - 183 WP_003409870.1 hypothetical protein -
O3Q54_RS10145 (O3Q54_10145) 2178487..2178837 - 351 WP_003899096.1 hypothetical protein -
O3Q54_RS10150 (O3Q54_10150) 2178848..2179750 - 903 WP_003899097.1 hypothetical protein -
O3Q54_RS10155 (O3Q54_10155) 2179771..2179962 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T282192 WP_003409778.1 NZ_CP125620:c2174746-2174417 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT282192 WP_003409780.1 NZ_CP125620:c2175120-2174743 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References