Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1938117..1938730 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag O3Q54_RS09040 Protein ID WP_003408465.1
Coordinates 1938117..1938506 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag O3Q54_RS09045 Protein ID WP_003408469.1
Coordinates 1938503..1938730 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS09005 (O3Q54_09005) 1933747..1934661 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
O3Q54_RS09010 (O3Q54_09010) 1934664..1935494 + 831 WP_003906661.1 cyclase family protein -
O3Q54_RS09015 (O3Q54_09015) 1935494..1935843 + 350 Protein_1779 cupin domain-containing protein -
O3Q54_RS09020 (O3Q54_09020) 1935896..1936714 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
O3Q54_RS09025 (O3Q54_09025) 1936728..1937507 + 780 WP_003408460.1 IclR family transcriptional regulator -
O3Q54_RS09035 (O3Q54_09035) 1937938..1938069 + 132 Protein_1782 IS3 family transposase -
O3Q54_RS09040 (O3Q54_09040) 1938117..1938506 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS09045 (O3Q54_09045) 1938503..1938730 - 228 WP_003408469.1 antitoxin Antitoxin
O3Q54_RS09050 (O3Q54_09050) 1938948..1940432 + 1485 WP_009937637.1 biotin carboxylase -
O3Q54_RS09055 (O3Q54_09055) 1940429..1941676 + 1248 WP_003408476.1 serine hydrolase -
O3Q54_RS09060 (O3Q54_09060) 1941719..1942138 - 420 WP_003408483.1 hypothetical protein -
O3Q54_RS09065 (O3Q54_09065) 1942128..1942838 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T282190 WP_003408465.1 NZ_CP125620:c1938506-1938117 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT282190 WP_003408469.1 NZ_CP125620:c1938730-1938503 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References