Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1765095..1765708 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag O3Q54_RS08290 Protein ID WP_003407786.1
Coordinates 1765304..1765708 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag O3Q54_RS08285 Protein ID WP_009935474.1
Coordinates 1765095..1765298 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS08255 (O3Q54_08255) 1760500..1760880 + 381 WP_003407768.1 fumarate reductase subunit C -
O3Q54_RS08260 (O3Q54_08260) 1760877..1761254 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
O3Q54_RS08265 (O3Q54_08265) 1761322..1761930 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
O3Q54_RS08270 (O3Q54_08270) 1762114..1763262 + 1149 Protein_1631 MMPL family transporter -
O3Q54_RS08275 (O3Q54_08275) 1763272..1763718 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
O3Q54_RS08280 (O3Q54_08280) 1763753..1765042 + 1290 WP_003407781.1 threonine ammonia-lyase -
O3Q54_RS08285 (O3Q54_08285) 1765095..1765298 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
O3Q54_RS08290 (O3Q54_08290) 1765304..1765708 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
O3Q54_RS08295 (O3Q54_08295) 1765725..1767467 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
O3Q54_RS08300 (O3Q54_08300) 1767460..1769757 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T282189 WP_003407786.1 NZ_CP125620:1765304-1765708 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT282189 WP_009935474.1 NZ_CP125620:1765095-1765298 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References