Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1574196..1574851 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag O3Q54_RS07445 Protein ID WP_003898861.1
Coordinates 1574196..1574597 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag O3Q54_RS07450 Protein ID WP_003407272.1
Coordinates 1574594..1574851 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS07430 (O3Q54_07430) 1569669..1571054 - 1386 WP_003407260.1 cytochrome P450 -
O3Q54_RS07435 (O3Q54_07435) 1571132..1572166 + 1035 WP_003407264.1 AraC family transcriptional regulator -
O3Q54_RS07440 (O3Q54_07440) 1572212..1573941 - 1730 Protein_1465 PE family protein -
O3Q54_RS07445 (O3Q54_07445) 1574196..1574597 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS07450 (O3Q54_07450) 1574594..1574851 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
O3Q54_RS07455 (O3Q54_07455) 1574934..1575893 - 960 WP_003407276.1 alpha/beta hydrolase -
O3Q54_RS07460 (O3Q54_07460) 1575918..1576880 - 963 WP_003407279.1 alpha/beta hydrolase -
O3Q54_RS07465 (O3Q54_07465) 1576879..1577616 + 738 WP_031647000.1 lysoplasmalogenase -
O3Q54_RS07470 (O3Q54_07470) 1577697..1579664 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T282187 WP_003898861.1 NZ_CP125620:c1574597-1574196 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT282187 WP_003407272.1 NZ_CP125620:c1574851-1574594 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References