Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1539833..1540883 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag O3Q54_RS07295 Protein ID WP_003407164.1
Coordinates 1539833..1540654 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag O3Q54_RS07300 Protein ID WP_003407167.1
Coordinates 1540647..1540883 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS07275 (O3Q54_07275) 1535400..1536062 - 663 WP_003407152.1 membrane protein -
O3Q54_RS07280 (O3Q54_07280) 1536059..1536835 - 777 WP_014585516.1 hypothetical protein -
O3Q54_RS07285 (O3Q54_07285) 1537126..1539087 - 1962 WP_003407159.1 sigma-F factor regulator -
O3Q54_RS07290 (O3Q54_07290) 1539226..1539612 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
O3Q54_RS07295 (O3Q54_07295) 1539833..1540654 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
O3Q54_RS07300 (O3Q54_07300) 1540647..1540883 + 237 WP_003407167.1 hypothetical protein Antitoxin
O3Q54_RS07305 (O3Q54_07305) 1540955..1542160 - 1206 WP_003898846.1 serine hydrolase domain-containing protein -
O3Q54_RS07310 (O3Q54_07310) 1542463..1543248 + 786 WP_003407180.1 lipoprotein LprF -
O3Q54_RS07315 (O3Q54_07315) 1543444..1544913 + 1470 WP_003900326.1 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T282186 WP_003407164.1 NZ_CP125620:1539833-1540654 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT282186 WP_003407167.1 NZ_CP125620:1540647-1540883 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References