Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1390193..1390752 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag O3Q54_RS06645 Protein ID WP_003898789.1
Coordinates 1390193..1390486 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag O3Q54_RS06650 Protein ID WP_003406322.1
Coordinates 1390483..1390752 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS06620 (O3Q54_06620) 1385786..1386046 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
O3Q54_RS06625 (O3Q54_06625) 1386043..1386474 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
O3Q54_RS06630 (O3Q54_06630) 1386497..1388185 - 1689 WP_003910308.1 PE family protein -
O3Q54_RS06635 (O3Q54_06635) 1388365..1389225 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
O3Q54_RS06640 (O3Q54_06640) 1389306..1390136 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
O3Q54_RS06645 (O3Q54_06645) 1390193..1390486 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
O3Q54_RS06650 (O3Q54_06650) 1390483..1390752 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O3Q54_RS06655 (O3Q54_06655) 1390865..1394560 - 3696 WP_009938349.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
O3Q54_RS06660 (O3Q54_06660) 1394702..1395490 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T282185 WP_003898789.1 NZ_CP125620:c1390486-1390193 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT282185 WP_003406322.1 NZ_CP125620:c1390752-1390483 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References