Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1385786..1386474 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag O3Q54_RS06625 Protein ID WP_003406304.1
Coordinates 1386043..1386474 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag O3Q54_RS06620 Protein ID WP_003406302.1
Coordinates 1385786..1386046 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS06600 (O3Q54_06600) 1381363..1382187 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
O3Q54_RS06605 (O3Q54_06605) 1382192..1383373 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
O3Q54_RS06610 (O3Q54_06610) 1383450..1384550 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
O3Q54_RS06615 (O3Q54_06615) 1384721..1385710 + 990 WP_003406301.1 malate dehydrogenase -
O3Q54_RS06620 (O3Q54_06620) 1385786..1386046 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
O3Q54_RS06625 (O3Q54_06625) 1386043..1386474 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS06630 (O3Q54_06630) 1386497..1388185 - 1689 WP_003910308.1 PE family protein -
O3Q54_RS06635 (O3Q54_06635) 1388365..1389225 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
O3Q54_RS06640 (O3Q54_06640) 1389306..1390136 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
O3Q54_RS06645 (O3Q54_06645) 1390193..1390486 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
O3Q54_RS06650 (O3Q54_06650) 1390483..1390752 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T282184 WP_003406304.1 NZ_CP125620:1386043-1386474 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT282184 WP_003406302.1 NZ_CP125620:1385786-1386046 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References