Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1016505..1017124 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag O3Q54_RS04820 Protein ID WP_003404726.1
Coordinates 1016690..1017124 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag O3Q54_RS04815 Protein ID WP_003898641.1
Coordinates 1016505..1016684 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS04800 (O3Q54_04800) 1011978..1013558 + 1581 WP_003909313.1 serine hydrolase -
O3Q54_RS04805 (O3Q54_04805) 1013555..1015948 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
O3Q54_RS04810 (O3Q54_04810) 1016221..1016379 + 159 WP_003404720.1 hypothetical protein -
O3Q54_RS04815 (O3Q54_04815) 1016505..1016684 + 180 WP_003898641.1 antitoxin Antitoxin
O3Q54_RS04820 (O3Q54_04820) 1016690..1017124 + 435 WP_003404726.1 SRPBCC family protein Toxin
O3Q54_RS04825 (O3Q54_04825) 1017222..1017995 + 774 WP_003404735.1 VOC family protein -
O3Q54_RS04830 (O3Q54_04830) 1018060..1018509 + 450 WP_003404738.1 hypothetical protein -
O3Q54_RS04835 (O3Q54_04835) 1018644..1018874 - 231 WP_003898642.1 hypothetical protein -
O3Q54_RS04840 (O3Q54_04840) 1019041..1020549 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
O3Q54_RS04845 (O3Q54_04845) 1020551..1021789 - 1239 WP_031713722.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T282179 WP_003404726.1 NZ_CP125620:1016690-1017124 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT282179 WP_003898641.1 NZ_CP125620:1016505-1016684 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References