Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 841476..842185 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag O3Q54_RS03970 Protein ID WP_003403837.1
Coordinates 841757..842185 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag O3Q54_RS03965 Protein ID WP_003403834.1
Coordinates 841476..841733 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS03960 (O3Q54_03960) 838980..841385 + 2406 WP_012054245.1 PE family protein -
O3Q54_RS03965 (O3Q54_03965) 841476..841733 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
O3Q54_RS03970 (O3Q54_03970) 841757..842185 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS03975 (O3Q54_03975) 842266..842403 - 138 WP_003403839.1 hypothetical protein -
O3Q54_RS03980 (O3Q54_03980) 842562..842807 + 246 WP_003403841.1 hypothetical protein -
O3Q54_RS03985 (O3Q54_03985) 842876..843760 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
O3Q54_RS03990 (O3Q54_03990) 843771..844943 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
O3Q54_RS03995 (O3Q54_03995) 844950..846482 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T282178 WP_003403837.1 NZ_CP125620:841757-842185 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT282178 WP_003403834.1 NZ_CP125620:841476-841733 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References