Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 755348..756140 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag O3Q54_RS03490 Protein ID WP_003403386.1
Coordinates 755703..756140 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag O3Q54_RS03485 Protein ID WP_003403381.1
Coordinates 755348..755593 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS03455 (O3Q54_03455) 750368..751873 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
O3Q54_RS03460 (O3Q54_03460) 751954..752964 + 1011 WP_009937374.1 ABC transporter ATP-binding protein -
O3Q54_RS03465 (O3Q54_03465) 753352..753735 - 384 WP_003403365.1 ribonuclease VapC6 -
O3Q54_RS03470 (O3Q54_03470) 753830..753985 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
O3Q54_RS03475 (O3Q54_03475) 754061..754777 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
O3Q54_RS03480 (O3Q54_03480) 755053..755361 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
O3Q54_RS03485 (O3Q54_03485) 755348..755593 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
O3Q54_RS03490 (O3Q54_03490) 755703..756140 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS03495 (O3Q54_03495) 756137..756391 - 255 WP_003911263.1 antitoxin VapB7 -
O3Q54_RS03500 (O3Q54_03500) 756505..758868 + 2364 WP_003898547.1 arylsulfatase AtsD -
O3Q54_RS03505 (O3Q54_03505) 758931..759257 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
O3Q54_RS03510 (O3Q54_03510) 759169..759507 + 339 WP_003403405.1 PIN domain-containing protein -
O3Q54_RS03515 (O3Q54_03515) 759504..759677 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T282176 WP_003403386.1 NZ_CP125620:c756140-755703 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT282176 WP_003403381.1 NZ_CP125620:c755593-755348 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References