Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 716245..716894 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag O3Q54_RS03280 Protein ID WP_003403236.1
Coordinates 716499..716894 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag O3Q54_RS03275 Protein ID WP_003403235.1
Coordinates 716245..716499 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS03250 (O3Q54_03250) 711371..711454 + 84 Protein_644 galactose-1-phosphate uridylyltransferase -
O3Q54_RS03255 (O3Q54_03255) 711473..712554 + 1082 Protein_645 galactose-1-phosphate uridylyltransferase -
O3Q54_RS03260 (O3Q54_03260) 712551..713642 + 1092 WP_003906403.1 galactokinase -
O3Q54_RS03265 (O3Q54_03265) 714037..715101 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
O3Q54_RS03270 (O3Q54_03270) 715205..716152 + 948 WP_003403232.1 DUF732 domain-containing protein -
O3Q54_RS03275 (O3Q54_03275) 716245..716499 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
O3Q54_RS03280 (O3Q54_03280) 716499..716894 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
O3Q54_RS03285 (O3Q54_03285) 716988..717728 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
O3Q54_RS03290 (O3Q54_03290) 717860..718120 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
O3Q54_RS03295 (O3Q54_03295) 718117..718524 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
O3Q54_RS03300 (O3Q54_03300) 718596..719747 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
O3Q54_RS03305 (O3Q54_03305) 719840..721567 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T282172 WP_003403236.1 NZ_CP125620:716499-716894 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT282172 WP_003403235.1 NZ_CP125620:716245-716499 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References