Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710617..711242 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag O3Q54_RS03245 Protein ID WP_003403218.1
Coordinates 710841..711242 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag O3Q54_RS03240 Protein ID WP_003403213.1
Coordinates 710617..710844 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS03215 (O3Q54_03215) 705796..706017 - 222 WP_003898525.1 DUF4926 domain-containing protein -
O3Q54_RS03220 (O3Q54_03220) 706159..706764 + 606 WP_003898526.1 hypothetical protein -
O3Q54_RS03225 (O3Q54_03225) 706783..709350 - 2568 WP_009937370.1 SEC-C metal-binding domain-containing protein -
O3Q54_RS03230 (O3Q54_03230) 709434..710183 + 750 WP_003898528.1 hypothetical protein -
O3Q54_RS03235 (O3Q54_03235) 710180..710422 + 243 WP_003403210.1 hypothetical protein -
O3Q54_RS03240 (O3Q54_03240) 710617..710844 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
O3Q54_RS03245 (O3Q54_03245) 710841..711242 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
O3Q54_RS03250 (O3Q54_03250) 711371..711454 + 84 Protein_644 galactose-1-phosphate uridylyltransferase -
O3Q54_RS03255 (O3Q54_03255) 711473..712554 + 1082 Protein_645 galactose-1-phosphate uridylyltransferase -
O3Q54_RS03260 (O3Q54_03260) 712551..713642 + 1092 WP_003906403.1 galactokinase -
O3Q54_RS03265 (O3Q54_03265) 714037..715101 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
O3Q54_RS03270 (O3Q54_03270) 715205..716152 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T282171 WP_003403218.1 NZ_CP125620:710841-711242 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT282171 WP_003403213.1 NZ_CP125620:710617-710844 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References