Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 703079..703722 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag O3Q54_RS03195 Protein ID WP_003403187.1
Coordinates 703321..703722 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag O3Q54_RS03190 Protein ID WP_003403184.1
Coordinates 703079..703324 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS03155 (O3Q54_03155) 698359..698889 - 531 WP_003917320.1 two component system sensor kinase HK2 -
O3Q54_RS03160 (O3Q54_03160) 698873..699568 - 696 WP_003918099.1 two-component system response regulator TcrA -
O3Q54_RS03165 (O3Q54_03165) 699691..700002 + 312 WP_003403164.1 hypothetical protein -
O3Q54_RS03170 (O3Q54_03170) 700074..701024 + 951 WP_003900184.1 DUF1259 domain-containing protein -
O3Q54_RS03175 (O3Q54_03175) 701265..701849 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
O3Q54_RS03180 (O3Q54_03180) 701851..702561 + 711 Protein_630 IS607 family element RNA-guided endonuclease TnpB -
O3Q54_RS03185 (O3Q54_03185) 702564..703034 + 471 WP_003898523.1 hypothetical protein -
O3Q54_RS03190 (O3Q54_03190) 703079..703324 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
O3Q54_RS03195 (O3Q54_03195) 703321..703722 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
O3Q54_RS03200 (O3Q54_03200) 703713..703892 + 180 Protein_634 hypothetical protein -
O3Q54_RS03205 (O3Q54_03205) 704310..704507 - 198 WP_003403191.1 hypothetical protein -
O3Q54_RS03210 (O3Q54_03210) 704587..705744 - 1158 WP_031713721.1 hypothetical protein -
O3Q54_RS03215 (O3Q54_03215) 705796..706017 - 222 WP_003898525.1 DUF4926 domain-containing protein -
O3Q54_RS03220 (O3Q54_03220) 706159..706764 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T282170 WP_003403187.1 NZ_CP125620:703321-703722 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT282170 WP_003403184.1 NZ_CP125620:703079-703324 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References