Detailed information of TA system TA028217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1416997..1417547
• Replicon: chromosome
• Accession: NC_018524
• Organism: Nocardiopsis alba ATCC BAA-2165

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B005_RS06235
• Protein ID: WP_041561729.1
• Coordinates: 1417278..1417547 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B005_RS06230
• Protein ID: WP_187294534.1
• Coordinates: 1416997..1417281 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B005_RS06200	1412170..1412406	-	237	WP_014910570.1	hypothetical protein	-
B005_RS06205	1412644..1413621	+	978	WP_014911455.1	R2-like ligand-binding oxidase	-
B005_RS06210	1413768..1414592	+	825	WP_014908733.1	DUF861 domain-containing protein	-
B005_RS06215	1414624..1415211	-	588	WP_014909456.1	scramblase	-
B005_RS06220	1415223..1416323	-	1101	WP_014913017.1	zeta toxin family protein	-
B005_RS06225	1416463..1416903	+	441	WP_014911689.1	NUDIX domain-containing protein	-
B005_RS06230	1416997..1417281	+	285	WP_187294534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B005_RS06235	1417278..1417547	+	270	WP_041561729.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B005_RS06240	1417555..1418439	-	885	WP_014910034.1	CPBP family intramembrane metalloprotease	-
B005_RS06245	1418580..1420316	+	1737	WP_014913609.1	ABC transporter ATP-binding protein/permease	-
B005_RS06250	1420313..1422151	+	1839	WP_014913192.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-64)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10350.03 Da
• Isoelectric Point: 10.7753

>T28217 WP_041561729.1 NC_018524:1417278-1417547 [Nocardiopsis alba ATCC BAA-2165]
VSYRTVFRPEARSELRKLPRNVAMTVFRKLTELERDPLGFGTTALVGAPEIRRLRVGDYRVVYTVENEKLIIWVVHVGHR
SSVYDRPLP

Nucleotide

• Length: 270 bp

>T28217 NC_018524:1417278-1417547 [Nocardiopsis alba ATCC BAA-2165]
GTGAGCTACCGAACCGTCTTTCGACCGGAAGCCCGCTCGGAACTCCGCAAGCTTCCACGCAATGTCGCCATGACGGTGTT
CCGCAAGCTCACGGAACTGGAGCGGGACCCTCTGGGGTTCGGCACCACGGCGCTGGTGGGAGCCCCCGAGATCCGCCGTC
TACGAGTGGGCGATTATCGGGTCGTCTACACCGTGGAGAACGAGAAGCTCATCATCTGGGTGGTGCACGTCGGACACCGC
TCCAGCGTGTACGACCGACCCCTCCCGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10879.44 Da
• Isoelectric Point: 4.3170

>AT28217 WP_187294534.1 NC_018524:1416997-1417281 [Nocardiopsis alba ATCC BAA-2165]
MCTIGTMSEMQVESIRQVRDHIADVVDRADREDSPTVITRRGREVAAVVPIDLLRRYQQLEEQEIMRMVRERMNNPEPGI
PMEEVMAEILDGPE

Nucleotide

• Length: 285 bp

>AT28217 NC_018524:1416997-1417281 [Nocardiopsis alba ATCC BAA-2165]
ATGTGTACCATTGGGACCATGAGCGAGATGCAGGTGGAGTCCATTCGTCAGGTGCGTGATCACATCGCCGACGTCGTCGA
TCGTGCCGACAGGGAGGACTCACCGACCGTGATCACCAGACGCGGGAGAGAGGTCGCCGCCGTCGTCCCCATCGACCTCC
TGCGCAGATATCAGCAACTGGAAGAGCAGGAGATCATGCGCATGGTGCGTGAGCGCATGAACAACCCCGAACCCGGGATC
CCGATGGAAGAGGTCATGGCGGAGATCTTGGACGGCCCCGAGTGA