Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 366354..366997 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag O3Q54_RS01600 Protein ID WP_003401566.1
Coordinates 366572..366997 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag O3Q54_RS01595 Protein ID WP_003401563.1
Coordinates 366354..366575 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS01570 (O3Q54_01570) 361719..362522 - 804 WP_003401540.1 Stf0 family sulphotransferase -
O3Q54_RS01575 (O3Q54_01575) 362532..363929 - 1398 WP_003401544.1 sulfatase -
O3Q54_RS01580 (O3Q54_01580) 364108..365637 + 1530 WP_014585493.1 PE family protein -
O3Q54_RS01585 (O3Q54_01585) 365780..366007 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
O3Q54_RS01590 (O3Q54_01590) 366004..366306 + 303 WP_003401560.1 toxin-antitoxin system toxin -
O3Q54_RS01595 (O3Q54_01595) 366354..366575 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
O3Q54_RS01600 (O3Q54_01600) 366572..366997 + 426 WP_003401566.1 PIN domain nuclease Toxin
O3Q54_RS01605 (O3Q54_01605) 367133..367765 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
O3Q54_RS01610 (O3Q54_01610) 367762..368670 + 909 WP_003900117.1 protochlorophyllide reductase -
O3Q54_RS01615 (O3Q54_01615) 368678..369268 - 591 WP_229298012.1 hypothetical protein -
O3Q54_RS01620 (O3Q54_01620) 369261..369311 - 51 Protein_320 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T282164 WP_003401566.1 NZ_CP125620:366572-366997 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT282164 WP_003401563.1 NZ_CP125620:366354-366575 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References