Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 365780..366306 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag O3Q54_RS01590 Protein ID WP_003401560.1
Coordinates 366004..366306 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag O3Q54_RS01585 Protein ID WP_003401555.1
Coordinates 365780..366007 (+) Length 76 a.a.

Genomic Context

O3Q54_RS01565O3Q54_RS01580O3Q54_RS01585O3Q54_RS01590O3Q54_RS01595O3Q54_RS01600O3Q54_RS01605O3Q54_RS01610O3Q54_RS01570O3Q54_RS01575O3Q54_RS01615O3Q54_RS01620
Location: 360945..361730 (786 bp)
Type: Others
Protein ID: WP_003401538.1
Location: 364108..365637 (1530 bp)
Type: Others
Protein ID: WP_014585493.1
Location: 365780..366007 (228 bp)
Type: Antitoxin
Protein ID: WP_003401555.1
Location: 366004..366306 (303 bp)
Type: Toxin
Protein ID: WP_003401560.1
Location: 366354..366575 (222 bp)
Type: Others
Protein ID: WP_003401563.1
Location: 366572..366997 (426 bp)
Type: Others
Protein ID: WP_003401566.1
Location: 367133..367765 (633 bp)
Type: Others
Protein ID: WP_003401571.1
Location: 367762..368670 (909 bp)
Type: Others
Protein ID: WP_003900117.1
Location: 361719..362522 (804 bp)
Type: Others
Protein ID: WP_003401540.1
Location: 362532..363929 (1398 bp)
Type: Others
Protein ID: WP_003401544.1
Location: 368678..369268 (591 bp)
Type: Others
Protein ID: WP_229298012.1
Location: 369261..369311 (51 bp)
Type: Others
Protein ID: Protein_320
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Q54_RS01565 (O3Q54_01565)360945..361730+786WP_003401538.1trans-aconitate 2-methyltransferase-
O3Q54_RS01570 (O3Q54_01570)361719..362522-804WP_003401540.1Stf0 family sulphotransferase-
O3Q54_RS01575 (O3Q54_01575)362532..363929-1398WP_003401544.1sulfatase-
O3Q54_RS01580 (O3Q54_01580)364108..365637+1530WP_014585493.1PE family protein-
O3Q54_RS01585 (O3Q54_01585)365780..366007+228WP_003401555.1ribbon-helix-helix protein, CopG familyAntitoxin
O3Q54_RS01590 (O3Q54_01590)366004..366306+303WP_003401560.1toxin-antitoxin system toxinToxin
O3Q54_RS01595 (O3Q54_01595)366354..366575+222WP_003401563.1type II toxin-antitoxin system antitoxin VapB2-
O3Q54_RS01600 (O3Q54_01600)366572..366997+426WP_003401566.1PIN domain nuclease-
O3Q54_RS01605 (O3Q54_01605)367133..367765+633WP_003401571.1TetR/AcrR family transcriptional regulator-
O3Q54_RS01610 (O3Q54_01610)367762..368670+909WP_003900117.1protochlorophyllide reductase-
O3Q54_RS01615 (O3Q54_01615)368678..369268-591WP_229298012.1hypothetical protein-
O3Q54_RS01620 (O3Q54_01620)369261..369311-51Protein_320hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T282162 WP_003401560.1 NZ_CP125620:366004-366306 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT282162 WP_003401555.1 NZ_CP125620:365780-366007 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4F8T1

References