Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 71627..72260 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag O3Q54_RS00360 Protein ID WP_003400580.1
Coordinates 71859..72260 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag O3Q54_RS00355 Protein ID WP_003400577.1
Coordinates 71627..71866 (+) Length 80 a.a.

Genomic Context

O3Q54_RS00340O3Q54_RS00345O3Q54_RS00350O3Q54_RS00355O3Q54_RS00360O3Q54_RS00375O3Q54_RS00365O3Q54_RS00370
Location: 66924..68363 (1440 bp)
Type: Others
Protein ID: WP_003901784.1
Location: 68419..68580 (162 bp)
Type: Others
Protein ID: WP_003899796.1
Location: 68621..71560 (2940 bp)
Type: Others
Protein ID: WP_031648427.1
Location: 71627..71866 (240 bp)
Type: Antitoxin
Protein ID: WP_003400577.1
Location: 71859..72260 (402 bp)
Type: Toxin
Protein ID: WP_003400580.1
Location: 75339..76250 (912 bp)
Type: Others
Protein ID: WP_003899798.1
Location: 72312..74549 (2238 bp)
Type: Others
Protein ID: WP_003899797.1
Location: 74667..75236 (570 bp)
Type: Others
Protein ID: WP_003400591.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Q54_RS00340 (O3Q54_00340)66924..68363+1440WP_003901784.1FAD-binding oxidoreductase-
O3Q54_RS00345 (O3Q54_00345)68419..68580+162WP_003899796.1hypothetical protein-
O3Q54_RS00350 (O3Q54_00350)68621..71560+2940WP_031648427.1UPF0182 family protein-
O3Q54_RS00355 (O3Q54_00355)71627..71866+240WP_003400577.1antitoxin VapB1Antitoxin
O3Q54_RS00360 (O3Q54_00360)71859..72260+402WP_003400580.1type II toxin-antitoxin system ribonuclease VapC1Toxin
O3Q54_RS00365 (O3Q54_00365)72312..74549-2238WP_003899797.1NADP-dependent isocitrate dehydrogenase-
O3Q54_RS00370 (O3Q54_00370)74667..75236-570WP_003400591.1TetR/AcrR family transcriptional regulator-
O3Q54_RS00375 (O3Q54_00375)75339..76250+912WP_003899798.1SDR family NAD(P)-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T282161 WP_003400580.1 NZ_CP125620:71859-72260 [Mycobacterium tuberculosis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT282161 WP_003400577.1 NZ_CP125620:71627-71866 [Mycobacterium tuberculosis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4BR82

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829CHM7

References