Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 247521..248164 Replicon chromosome
Accession NZ_CP125619
Organism Pseudomonas sp. PMCC200367

Toxin (Protein)


Gene name hicA Uniprot ID A0A0Q6Q0X4
Locus tag QFX16_RS01115 Protein ID WP_046045491.1
Coordinates 247521..247703 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QFX16_RS01120 Protein ID WP_283182495.1
Coordinates 247700..248164 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFX16_RS01095 243292..244218 + 927 WP_283182494.1 serine acetyltransferase -
QFX16_RS01100 244715..246670 + 1956 WP_283184499.1 choline transporter BetT -
QFX16_RS01105 246679..246939 - 261 WP_095127627.1 hypothetical protein -
QFX16_RS01110 247075..247380 - 306 WP_283184500.1 SDR family oxidoreductase -
QFX16_RS01115 247521..247703 + 183 WP_046045491.1 type II toxin-antitoxin system HicA family toxin Toxin
QFX16_RS01120 247700..248164 + 465 WP_283182495.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QFX16_RS01125 248336..249373 + 1038 WP_283182496.1 L-glyceraldehyde 3-phosphate reductase -
QFX16_RS01130 249425..250267 - 843 WP_283182497.1 taurine dioxygenase -
QFX16_RS01135 250328..251161 - 834 WP_283182498.1 taurine ABC transporter permease TauC -
QFX16_RS01140 251158..251952 - 795 WP_283182499.1 taurine ABC transporter ATP-binding subunit -
QFX16_RS01145 251968..252945 - 978 WP_008149275.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(24-148)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6883.05 Da        Isoelectric Point: 10.3203

>T282154 WP_046045491.1 NZ_CP125619:247521-247703 [Pseudomonas sp. PMCC200367]
MRSREMIRMIEEDGWYLVAVKGSHHQYKHPCKPGRVTIKHPDSDLPKGTINSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16816.65 Da        Isoelectric Point: 4.2687

>AT282154 WP_283182495.1 NZ_CP125619:247700-248164 [Pseudomonas sp. PMCC200367]
MSPDTGYESPERATSQEGLSEMKFPVVLHKDADSEYGVIIPDVPGCFSAGGTVAQAFENVKEALSLHYEGLVADGDPLPQ
VHEIDAHLDNPDYAGGVWGVVEFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Download         Length: 465 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q6Q0X4

Antitoxin

Source ID Structure

References