Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2462694..2463298 Replicon chromosome
Accession NZ_CP125618
Organism Pseudomonas sp. PMCC200344

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag QFW87_RS11145 Protein ID WP_283190506.1
Coordinates 2463005..2463298 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W6VBC7
Locus tag QFW87_RS11140 Protein ID WP_008153842.1
Coordinates 2462694..2463002 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW87_RS11120 2458406..2459899 + 1494 WP_283190503.1 ATP-binding protein -
QFW87_RS11125 2459868..2461298 + 1431 WP_283190504.1 sigma-54 dependent transcriptional regulator -
QFW87_RS11130 2461302..2461688 - 387 WP_283183929.1 hypothetical protein -
QFW87_RS11135 2461868..2462680 + 813 WP_283190505.1 methyltransferase domain-containing protein -
QFW87_RS11140 2462694..2463002 - 309 WP_008153842.1 putative addiction module antidote protein Antitoxin
QFW87_RS11145 2463005..2463298 - 294 WP_283190506.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFW87_RS11150 2463463..2464131 + 669 WP_283190507.1 ABC transporter ATP-binding protein -
QFW87_RS11155 2464133..2466604 + 2472 WP_283190903.1 FtsX-like permease family protein -
QFW87_RS11160 2466594..2467658 + 1065 WP_283190508.1 lipocalin-like domain-containing protein -
QFW87_RS11165 2467721..2467963 + 243 WP_283190509.1 hypothetical protein -
QFW87_RS11170 2467975..2468142 + 168 WP_162842855.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10680.42 Da        Isoelectric Point: 10.8628

>T282152 WP_283190506.1 NZ_CP125618:c2463298-2463005 [Pseudomonas sp. PMCC200344]
MNYLIQQTMIFATWHASVRDLRAKLAIARRIDRASAGNLGDIKPVGDGVSEMRVDVGAGYRVYFTMRNSVVIVLLAGGDK
SSQTADIRRAKKLAKEV

Download         Length: 294 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11017.53 Da        Isoelectric Point: 5.0344

>AT282152 WP_008153842.1 NZ_CP125618:c2463002-2462694 [Pseudomonas sp. PMCC200344]
MSQTLTTFDMAALLDSDEAISEYLSQVLADGDNEEFLRAIGYVVKARGMTQIAKDSGMGRESLYKAFAPGAKPRFDTVLK
VIHALGIDLCAQPGHSVNHSTL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W6VBC7

References