Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1878131..1878747 Replicon chromosome
Accession NZ_CP125618
Organism Pseudomonas sp. PMCC200344

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QFW87_RS08425 Protein ID WP_283190259.1
Coordinates 1878131..1878343 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QFW87_RS08430 Protein ID WP_283183592.1
Coordinates 1878343..1878747 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW87_RS08395 1873632..1874105 + 474 WP_283190256.1 cytochrome c-type biogenesis protein CcmH -
QFW87_RS08400 1874098..1875300 + 1203 WP_283183587.1 c-type cytochrome biogenesis protein CcmI -
QFW87_RS08405 1875315..1875719 + 405 WP_283183588.1 hypothetical protein -
QFW87_RS08410 1875940..1876407 - 468 WP_283190257.1 helix-turn-helix domain-containing protein -
QFW87_RS08415 1876527..1877000 - 474 Protein_1657 LysR family transcriptional regulator -
QFW87_RS08420 1877131..1877850 - 720 WP_283190258.1 SDR family oxidoreductase -
QFW87_RS08425 1878131..1878343 + 213 WP_283190259.1 type II toxin-antitoxin system HicA family toxin Toxin
QFW87_RS08430 1878343..1878747 + 405 WP_283183592.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QFW87_RS08435 1878808..1880013 - 1206 WP_283190260.1 MFS transporter -
QFW87_RS08440 1880327..1881325 - 999 WP_283183594.1 sulfate ABC transporter substrate-binding protein -
QFW87_RS08445 1881440..1882264 - 825 WP_283183595.1 ion transporter -
QFW87_RS08450 1882286..1883209 - 924 WP_283190261.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7921.23 Da        Isoelectric Point: 9.8888

>T282151 WP_283190259.1 NZ_CP125618:1878131-1878343 [Pseudomonas sp. PMCC200344]
VQSRLLIKELEEAGWILDRIAGSHHLFKHRYNPYTIPVPHPKKDLPIGTVKCIRRRAGLYCPGASYAGDP

Download         Length: 213 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14761.76 Da        Isoelectric Point: 4.3841

>AT282151 WP_283183592.1 NZ_CP125618:1878343-1878747 [Pseudomonas sp. PMCC200344]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAVEIAHIMLQEIAADGESIPMPTSAAVHRGNPDFADMGWGM
LELDIAPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References