Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4839581..4840097 Replicon chromosome
Accession NC_018522
Organism Klebsiella pneumoniae subsp. pneumoniae 1084

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag A79E_RS23400 Protein ID WP_004178374.1
Coordinates 4839581..4839865 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag A79E_RS23405 Protein ID WP_002886901.1
Coordinates 4839855..4840097 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A79E_RS23370 4834977..4835285 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
A79E_RS28970 4835370..4835543 + 174 WP_041169004.1 hypothetical protein -
A79E_RS23380 4835546..4836289 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
A79E_RS23390 4836646..4838784 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
A79E_RS23395 4839113..4839577 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A79E_RS23400 4839581..4839865 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A79E_RS23405 4839855..4840097 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A79E_RS23410 4840175..4842085 - 1911 WP_012737231.1 BglG family transcription antiterminator -
A79E_RS23415 4842108..4843262 - 1155 WP_012737230.1 lactonase family protein -
A79E_RS23420 4843329..4844069 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T28215 WP_004178374.1 NC_018522:c4839865-4839581 [Klebsiella pneumoniae subsp. pneumoniae 1084]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T28215 NC_018522:c4839865-4839581 [Klebsiella pneumoniae subsp. pneumoniae 1084]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT28215 WP_002886901.1 NC_018522:c4840097-4839855 [Klebsiella pneumoniae subsp. pneumoniae 1084]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT28215 NC_018522:c4840097-4839855 [Klebsiella pneumoniae subsp. pneumoniae 1084]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References