Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5745788..5746374 Replicon chromosome
Accession NZ_CP125365
Organism Pseudomonas aeruginosa strain ZY36

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag QMK42_RS26770 Protein ID WP_003120987.1
Coordinates 5746075..5746374 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag QMK42_RS26765 Protein ID WP_003448662.1
Coordinates 5745788..5746078 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK42_RS26750 (QMK42_26750) 5741370..5743259 + 1890 WP_196994395.1 hypothetical protein -
QMK42_RS26755 (QMK42_26755) 5743256..5745232 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
QMK42_RS26760 (QMK42_26760) 5745373..5745717 + 345 WP_016851612.1 hypothetical protein -
QMK42_RS26765 (QMK42_26765) 5745788..5746078 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
QMK42_RS26770 (QMK42_26770) 5746075..5746374 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMK42_RS26775 (QMK42_26775) 5746576..5747700 + 1125 WP_012076859.1 TcpQ domain-containing protein -
QMK42_RS26780 (QMK42_26780) 5747700..5749409 + 1710 WP_003099757.1 PilN family type IVB pilus formation outer membrane protein -
QMK42_RS26785 (QMK42_26785) 5749413..5750738 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
QMK42_RS26790 (QMK42_26790) 5750728..5751261 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5717759..5804971 87212


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T282137 WP_003120987.1 NZ_CP125365:c5746374-5746075 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT282137 WP_003448662.1 NZ_CP125365:c5746078-5745788 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References