Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3841691..3842911 | Replicon | chromosome |
| Accession | NZ_CP125365 | ||
| Organism | Pseudomonas aeruginosa strain ZY36 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | QMK42_RS17645 | Protein ID | WP_003160088.1 |
| Coordinates | 3842333..3842911 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | QMK42_RS17640 | Protein ID | WP_003088112.1 |
| Coordinates | 3841691..3842245 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMK42_RS17615 (QMK42_17615) | 3837259..3837810 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
| QMK42_RS17620 (QMK42_17620) | 3837807..3838205 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| QMK42_RS17625 (QMK42_17625) | 3838218..3838541 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| QMK42_RS17630 (QMK42_17630) | 3838872..3839333 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| QMK42_RS17635 (QMK42_17635) | 3839338..3841533 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| QMK42_RS17640 (QMK42_17640) | 3841691..3842245 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| QMK42_RS17645 (QMK42_17645) | 3842333..3842911 | + | 579 | WP_003160088.1 | HD domain-containing protein | Toxin |
| QMK42_RS17650 (QMK42_17650) | 3843020..3844207 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| QMK42_RS17655 (QMK42_17655) | 3844197..3846368 | - | 2172 | WP_009876279.1 | type I secretion system permease/ATPase | - |
| QMK42_RS17660 (QMK42_17660) | 3846358..3847635 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21816.65 Da Isoelectric Point: 5.1625
>T282135 WP_003160088.1 NZ_CP125365:3842333-3842911 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT282135 WP_003088112.1 NZ_CP125365:3841691-3842245 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|