Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1907616..1909124 Replicon chromosome
Accession NZ_CP125365
Organism Pseudomonas aeruginosa strain ZY36

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag QMK42_RS08940 Protein ID WP_003119682.1
Coordinates 1907616..1908203 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag QMK42_RS08945 Protein ID WP_003119683.1
Coordinates 1908270..1909124 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK42_RS08935 (QMK42_08935) 1903871..1907350 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
QMK42_RS08940 (QMK42_08940) 1907616..1908203 + 588 WP_003119682.1 GNAT family protein Toxin
QMK42_RS08945 (QMK42_08945) 1908270..1909124 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
QMK42_RS08950 (QMK42_08950) 1909221..1911386 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
QMK42_RS08955 (QMK42_08955) 1911561..1913435 + 1875 WP_003091605.1 MFS transporter -
QMK42_RS08960 (QMK42_08960) 1913496..1913705 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T282134 WP_003119682.1 NZ_CP125365:1907616-1908203 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT282134 WP_003119683.1 NZ_CP125365:1908270-1909124 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References