Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4083309..4083928 Replicon chromosome
Accession NC_018522
Organism Klebsiella pneumoniae subsp. pneumoniae 1084

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag A79E_RS19735 Protein ID WP_002892050.1
Coordinates 4083710..4083928 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag A79E_RS19730 Protein ID WP_002892066.1
Coordinates 4083309..4083683 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A79E_RS19720 4078461..4079654 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A79E_RS19725 4079677..4082823 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
A79E_RS19730 4083309..4083683 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
A79E_RS19735 4083710..4083928 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
A79E_RS19740 4084087..4084653 + 567 WP_002892030.1 maltose O-acetyltransferase -
A79E_RS28905 4084625..4084765 - 141 WP_004147370.1 hypothetical protein -
A79E_RS19750 4084786..4085256 + 471 WP_002892026.1 YlaC family protein -
A79E_RS19755 4085231..4086682 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
A79E_RS19760 4086783..4087481 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
A79E_RS19765 4087478..4087618 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
A79E_RS19770 4087618..4087881 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T28213 WP_002892050.1 NC_018522:4083710-4083928 [Klebsiella pneumoniae subsp. pneumoniae 1084]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T28213 NC_018522:4083710-4083928 [Klebsiella pneumoniae subsp. pneumoniae 1084]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT28213 WP_002892066.1 NC_018522:4083309-4083683 [Klebsiella pneumoniae subsp. pneumoniae 1084]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT28213 NC_018522:4083309-4083683 [Klebsiella pneumoniae subsp. pneumoniae 1084]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References