Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4844190..4845448 Replicon chromosome
Accession NZ_CP125361
Organism Pseudomonas aeruginosa strain ZY94

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag QMK40_RS22540 Protein ID WP_003112528.1
Coordinates 4844190..4844945 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QMK40_RS22545 Protein ID WP_003086329.1
Coordinates 4845080..4845448 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK40_RS22530 (QMK40_22530) 4839363..4841906 + 2544 WP_031755663.1 acyl-homoserine-lactone acylase QuiP -
QMK40_RS22535 (QMK40_22535) 4842061..4843422 - 1362 WP_073647918.1 DNA recombination protein RmuC -
QMK40_RS22540 (QMK40_22540) 4844190..4844945 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
QMK40_RS22545 (QMK40_22545) 4845080..4845448 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QMK40_RS22550 (QMK40_22550) 4845521..4846807 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
QMK40_RS22555 (QMK40_22555) 4846863..4848356 - 1494 WP_031755661.1 aldehyde dehydrogenase family protein -
QMK40_RS22560 (QMK40_22560) 4848531..4849007 + 477 WP_003112531.1 hypothetical protein -
QMK40_RS22565 (QMK40_22565) 4849010..4849285 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T282122 WP_003112528.1 NZ_CP125361:c4844945-4844190 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT282122 WP_003086329.1 NZ_CP125361:c4845448-4845080 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References