Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1636885..1638580 Replicon chromosome
Accession NZ_CP125361
Organism Pseudomonas aeruginosa strain ZY94

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag QMK40_RS07675 Protein ID WP_003112901.1
Coordinates 1636885..1637754 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag QMK40_RS07680 Protein ID WP_003112902.1
Coordinates 1637747..1638580 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK40_RS07650 (QMK40_07650) 1632893..1633744 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
QMK40_RS07655 (QMK40_07655) 1633785..1634792 + 1008 WP_003162724.1 ABC transporter substrate-binding protein -
QMK40_RS07660 (QMK40_07660) 1634789..1635565 + 777 WP_003112898.1 ABC transporter permease -
QMK40_RS07665 (QMK40_07665) 1635571..1636332 + 762 WP_003112899.1 SDR family oxidoreductase -
QMK40_RS07670 (QMK40_07670) 1636346..1636876 + 531 WP_003112900.1 cupin domain-containing protein -
QMK40_RS07675 (QMK40_07675) 1636885..1637754 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
QMK40_RS07680 (QMK40_07680) 1637747..1638580 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
QMK40_RS07685 (QMK40_07685) 1638567..1639364 + 798 WP_017001845.1 SDR family oxidoreductase -
QMK40_RS07690 (QMK40_07690) 1639357..1641039 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
QMK40_RS07695 (QMK40_07695) 1641050..1641853 + 804 WP_003453564.1 aspartate dehydrogenase -
QMK40_RS07700 (QMK40_07700) 1641865..1643349 + 1485 WP_031756606.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T282119 WP_003112901.1 NZ_CP125361:1636885-1637754 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT282119 WP_003112902.1 NZ_CP125361:1637747-1638580 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References