Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 2085088..2086331 Replicon chromosome
Accession NZ_CP125359
Organism Streptococcus dysgalactiae subsp. equisimilis strain UT_10236

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag OPT60_RS10195 Protein ID WP_084916287.1
Coordinates 2085088..2085855 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag OPT60_RS10200 Protein ID WP_084916288.1
Coordinates 2085855..2086331 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPT60_RS10170 (OPT60_10170) 2080367..2081467 + 1101 WP_000168218.1 type IV secretion system DNA-binding domain-containing protein -
OPT60_RS10175 (OPT60_10175) 2081464..2082069 + 606 WP_084916284.1 hypothetical protein -
OPT60_RS10180 (OPT60_10180) 2082267..2082872 + 606 WP_001040933.1 replication protein -
OPT60_RS10185 (OPT60_10185) 2082865..2083113 + 249 WP_003055530.1 MerR family transcriptional regulator -
OPT60_RS10190 (OPT60_10190) 2083202..2084467 + 1266 WP_084916286.1 site-specific integrase -
OPT60_RS10195 (OPT60_10195) 2085088..2085855 - 768 WP_084916287.1 type II toxin-antitoxin system toxin PezT Toxin
OPT60_RS10200 (OPT60_10200) 2085855..2086331 - 477 WP_084916288.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
OPT60_RS10205 (OPT60_10205) 2086486..2086653 - 168 Protein_1954 peptidylprolyl isomerase -
OPT60_RS10210 (OPT60_10210) 2086916..2088079 - 1164 WP_084916290.1 MFS transporter -
OPT60_RS10215 (OPT60_10215) 2088066..2088842 - 777 WP_061600517.1 arginase family protein -
OPT60_RS10220 (OPT60_10220) 2088839..2090017 - 1179 WP_159333946.1 radical SAM protein -
OPT60_RS10225 (OPT60_10225) 2090108..2090971 - 864 WP_159333973.1 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2062882..2098848 35966
- flank IS/Tn - - 2090108..2090971 863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29124.02 Da        Isoelectric Point: 6.3943

>T282115 WP_084916287.1 NZ_CP125359:c2085855-2085088 [Streptococcus dysgalactiae subsp. equisimilis]
MKLEEFSQDNFEQASKRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
RYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPKKTAQLLTTKGYQVSLAVIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCIYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLKELGEIDK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18120.68 Da        Isoelectric Point: 4.6272

>AT282115 WP_084916288.1 NZ_CP125359:c2086331-2085855 [Streptococcus dysgalactiae subsp. equisimilis]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTKIYLVATFEDIERFNGYLDGIERMLEQATHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References