Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
Location | 890255..891687 | Replicon | chromosome |
Accession | NZ_CP125359 | ||
Organism | Streptococcus dysgalactiae subsp. equisimilis strain UT_10236 |
Toxin (Protein)
Gene name | abiEi | Uniprot ID | Q8DZ35 |
Locus tag | OPT60_RS04550 | Protein ID | WP_001030302.1 |
Coordinates | 890255..891100 (-) | Length | 282 a.a. |
Antitoxin (Protein)
Gene name | abiEii | Uniprot ID | Q8DZ36 |
Locus tag | OPT60_RS04555 | Protein ID | WP_000037239.1 |
Coordinates | 891097..891687 (-) | Length | 197 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OPT60_RS04545 (OPT60_04545) | 887368..890169 | + | 2802 | WP_000656698.1 | phage tail tip lysozyme | - |
OPT60_RS04550 (OPT60_04550) | 890255..891100 | - | 846 | WP_001030302.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
OPT60_RS04555 (OPT60_04555) | 891097..891687 | - | 591 | WP_000037239.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 282 a.a. Molecular weight: 32414.90 Da Isoelectric Point: 5.2111
>T282114 WP_001030302.1 NZ_CP125359:c891100-890255 [Streptococcus dysgalactiae subsp. equisimilis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD
Download Length: 846 bp
Antitoxin
Download Length: 197 a.a. Molecular weight: 23074.63 Da Isoelectric Point: 7.8056
>AT282114 WP_000037239.1 NZ_CP125359:c891687-891097 [Streptococcus dysgalactiae subsp. equisimilis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI
Download Length: 591 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A8D822 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 6Y8Q | |
AlphaFold DB | A0A2I7ZET8 |