Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3888628..3889282 Replicon chromosome
Accession NZ_CP125351
Organism Escherichia fergusonii strain XJ19MCE1

Toxin (Protein)


Gene name cptA Uniprot ID F0JPE9
Locus tag QKW25_RS19140 Protein ID WP_000244774.1
Coordinates 3888628..3889035 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QKW25_RS19145 Protein ID WP_000354046.1
Coordinates 3889016..3889282 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW25_RS19120 (3884586) 3884586..3886319 - 1734 WP_196082055.1 single-stranded-DNA-specific exonuclease RecJ -
QKW25_RS19125 (3886325) 3886325..3887035 - 711 WP_196082056.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QKW25_RS19130 (3887059) 3887059..3887955 - 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
QKW25_RS19135 (3888067) 3888067..3888588 + 522 WP_196082057.1 flavodoxin FldB -
QKW25_RS19140 (3888628) 3888628..3889035 - 408 WP_000244774.1 protein YgfX Toxin
QKW25_RS19145 (3889016) 3889016..3889282 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QKW25_RS19150 (3889534) 3889534..3890514 + 981 WP_196082058.1 tRNA-modifying protein YgfZ -
QKW25_RS19155 (3890535) 3890535..3891839 + 1305 WP_196082059.1 hypothetical protein -
QKW25_RS19160 (3891836) 3891836..3892303 + 468 WP_181667840.1 hypothetical protein -
QKW25_RS19165 (3892334) 3892334..3892993 - 660 WP_000250283.1 hemolysin III family protein -
QKW25_RS19170 (3893157) 3893157..3893468 - 312 WP_001182962.1 N(4)-acetylcytidine aminohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16078.05 Da        Isoelectric Point: 11.2511

>T282097 WP_000244774.1 NZ_CP125351:c3889035-3888628 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT282097 WP_000354046.1 NZ_CP125351:c3889282-3889016 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZX35

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References