Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3628251..3628870 Replicon chromosome
Accession NZ_CP125351
Organism Escherichia fergusonii strain XJ19MCE1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QKW25_RS17965 Protein ID WP_001280991.1
Coordinates 3628652..3628870 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag QKW25_RS17960 Protein ID WP_000344803.1
Coordinates 3628251..3628625 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW25_RS17950 (3623383) 3623383..3624576 + 1194 WP_196082219.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QKW25_RS17955 (3624599) 3624599..3627748 + 3150 WP_196082218.1 efflux RND transporter permease AcrB -
QKW25_RS17960 (3628251) 3628251..3628625 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
QKW25_RS17965 (3628652) 3628652..3628870 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QKW25_RS17970 (3629367) 3629367..3629837 + 471 WP_002431406.1 YlaC family protein -
QKW25_RS17975 (3629976) 3629976..3631526 + 1551 WP_283154465.1 EAL domain-containing protein -
QKW25_RS17980 (3631568) 3631568..3631921 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QKW25_RS17990 (3632300) 3632300..3632611 + 312 WP_196082216.1 MGMT family protein -
QKW25_RS17995 (3632642) 3632642..3633214 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T282094 WP_001280991.1 NZ_CP125351:3628652-3628870 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT282094 WP_000344803.1 NZ_CP125351:3628251-3628625 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References