Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1448397..1449022 Replicon chromosome
Accession NZ_CP125351
Organism Escherichia fergusonii strain XJ19MCE1

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag QKW25_RS07000 Protein ID WP_000911329.1
Coordinates 1448624..1449022 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QKW25_RS06995 Protein ID WP_000450524.1
Coordinates 1448397..1448624 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW25_RS06970 (1444200) 1444200..1444670 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
QKW25_RS06975 (1444670) 1444670..1445242 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
QKW25_RS06980 (1445389) 1445389..1446267 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
QKW25_RS06985 (1446284) 1446284..1447318 + 1035 WP_196081269.1 outer membrane protein assembly factor BamC -
QKW25_RS06990 (1447530) 1447530..1448243 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QKW25_RS06995 (1448397) 1448397..1448624 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QKW25_RS07000 (1448624) 1448624..1449022 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
QKW25_RS07005 (1449169) 1449169..1450032 + 864 WP_001267498.1 neutral zinc metallopeptidase -
QKW25_RS07010 (1450047) 1450047..1452062 + 2016 WP_196081268.1 tRNA cytosine(34) acetyltransferase TmcA -
QKW25_RS07015 (1452136) 1452136..1452834 + 699 WP_000679801.1 esterase -
QKW25_RS07020 (1452927) 1452927..1453127 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T282085 WP_000911329.1 NZ_CP125351:1448624-1449022 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT282085 WP_000450524.1 NZ_CP125351:1448397-1448624 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References