Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 76470..77380 | Replicon | plasmid pWYKP594-1 |
Accession | NZ_CP125350 | ||
Organism | Klebsiella pneumoniae strain WYKP594 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | QJR22_RS28805 | Protein ID | WP_004026354.1 |
Coordinates | 76470..76940 (-) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A6P1V3Q9 |
Locus tag | QJR22_RS28810 | Protein ID | WP_004026357.1 |
Coordinates | 76937..77380 (-) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QJR22_RS28780 (QJR22_28785) | 71882..72280 | - | 399 | WP_004212796.1 | H-NS family nucleoid-associated regulatory protein | - |
QJR22_RS28785 (QJR22_28790) | 72617..73111 | - | 495 | WP_004212794.1 | thermonuclease family protein | - |
QJR22_RS28790 (QJR22_28795) | 73289..73555 | + | 267 | WP_223175074.1 | DUF1173 family protein | - |
QJR22_RS28795 (QJR22_28800) | 73588..74238 | + | 651 | WP_068893702.1 | DUF1173 family protein | - |
QJR22_RS28805 (QJR22_28810) | 76470..76940 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
QJR22_RS28810 (QJR22_28815) | 76937..77380 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
QJR22_RS28815 (QJR22_28820) | 77481..77984 | - | 504 | Protein_82 | DUF4113 domain-containing protein | - |
QJR22_RS28820 (QJR22_28825) | 78190..79170 | - | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
QJR22_RS28825 (QJR22_28830) | 79236..80543 | + | 1308 | Protein_84 | FepA family TonB-dependent siderophore receptor | - |
QJR22_RS28830 (QJR22_28835) | 80605..80826 | + | 222 | WP_004213615.1 | hypothetical protein | - |
QJR22_RS28835 (QJR22_28840) | 80969..81871 | - | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
QJR22_RS28840 (QJR22_28845) | 81944..82345 | - | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | iroN / rmpA / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..217743 | 217743 | |
- | inside | IScluster/Tn | - | - | 70431..79170 | 8739 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T282079 WP_004026354.1 NZ_CP125350:c76940-76470 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT282079 WP_004026357.1 NZ_CP125350:c77380-76937 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6P1V3Q9 |