Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 76470..77380 Replicon plasmid pWYKP594-1
Accession NZ_CP125350
Organism Klebsiella pneumoniae strain WYKP594

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag QJR22_RS28805 Protein ID WP_004026354.1
Coordinates 76470..76940 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag QJR22_RS28810 Protein ID WP_004026357.1
Coordinates 76937..77380 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR22_RS28780 (QJR22_28785) 71882..72280 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
QJR22_RS28785 (QJR22_28790) 72617..73111 - 495 WP_004212794.1 thermonuclease family protein -
QJR22_RS28790 (QJR22_28795) 73289..73555 + 267 WP_223175074.1 DUF1173 family protein -
QJR22_RS28795 (QJR22_28800) 73588..74238 + 651 WP_068893702.1 DUF1173 family protein -
QJR22_RS28805 (QJR22_28810) 76470..76940 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
QJR22_RS28810 (QJR22_28815) 76937..77380 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
QJR22_RS28815 (QJR22_28820) 77481..77984 - 504 Protein_82 DUF4113 domain-containing protein -
QJR22_RS28820 (QJR22_28825) 78190..79170 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
QJR22_RS28825 (QJR22_28830) 79236..80543 + 1308 Protein_84 FepA family TonB-dependent siderophore receptor -
QJR22_RS28830 (QJR22_28835) 80605..80826 + 222 WP_004213615.1 hypothetical protein -
QJR22_RS28835 (QJR22_28840) 80969..81871 - 903 WP_004213613.1 DMT family inner membrane transporter PEG344 -
QJR22_RS28840 (QJR22_28845) 81944..82345 - 402 WP_214588034.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / rmpA / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..217743 217743
- inside IScluster/Tn - - 70431..79170 8739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T282079 WP_004026354.1 NZ_CP125350:c76940-76470 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT282079 WP_004026357.1 NZ_CP125350:c77380-76937 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References