282075

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4908249..4908765 Replicon chromosome
Accession NZ_CP125349
Organism Klebsiella pneumoniae strain WYKP594

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QJR22_RS25725 Protein ID WP_002886902.1
Coordinates 4908249..4908533 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QJR22_RS25730 Protein ID WP_002886901.1
Coordinates 4908523..4908765 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR22_RS25700 (QJR22_25705) 4903733..4903996 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QJR22_RS25705 (QJR22_25710) 4904126..4904299 + 174 WP_002886906.1 hypothetical protein -
QJR22_RS25710 (QJR22_25715) 4904302..4905045 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QJR22_RS25715 (QJR22_25720) 4905402..4907540 + 2139 WP_217289782.1 anaerobic ribonucleoside-triphosphate reductase -
QJR22_RS25720 (QJR22_25725) 4907781..4908245 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QJR22_RS25725 (QJR22_25730) 4908249..4908533 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJR22_RS25730 (QJR22_25735) 4908523..4908765 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QJR22_RS25735 (QJR22_25740) 4908843..4910753 - 1911 WP_004152270.1 PRD domain-containing protein -
QJR22_RS25740 (QJR22_25745) 4910776..4911930 - 1155 WP_002886900.1 lactonase family protein -
QJR22_RS25745 (QJR22_25750) 4911996..4912736 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T282075 WP_002886902.1 NZ_CP125349:c4908533-4908249 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT282075 WP_002886901.1 NZ_CP125349:c4908765-4908523 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References