282074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4190966..4191585 Replicon chromosome
Accession NZ_CP125349
Organism Klebsiella pneumoniae strain WYKP594

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QJR22_RS22275 Protein ID WP_002892050.1
Coordinates 4191367..4191585 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag QJR22_RS22270 Protein ID WP_002892066.1
Coordinates 4190966..4191340 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR22_RS22260 (QJR22_22265) 4186118..4187311 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QJR22_RS22265 (QJR22_22270) 4187334..4190480 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
QJR22_RS22270 (QJR22_22275) 4190966..4191340 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
QJR22_RS22275 (QJR22_22280) 4191367..4191585 + 219 WP_002892050.1 HHA domain-containing protein Toxin
QJR22_RS22280 (QJR22_22285) 4191744..4192310 + 567 WP_002892030.1 maltose O-acetyltransferase -
QJR22_RS22285 (QJR22_22290) 4192282..4192422 - 141 WP_004147370.1 hypothetical protein -
QJR22_RS22290 (QJR22_22295) 4192443..4192913 + 471 WP_002892026.1 YlaC family protein -
QJR22_RS22295 (QJR22_22300) 4192888..4194339 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
QJR22_RS22300 (QJR22_22305) 4194440..4195138 + 699 WP_002892021.1 GNAT family protein -
QJR22_RS22305 (QJR22_22310) 4195135..4195275 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
QJR22_RS22310 (QJR22_22315) 4195275..4195538 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T282074 WP_002892050.1 NZ_CP125349:4191367-4191585 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT282074 WP_002892066.1 NZ_CP125349:4190966-4191340 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References