Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2740522..2742110 Replicon chromosome
Accession NZ_CP125349
Organism Klebsiella pneumoniae strain WYKP594

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag QJR22_RS14975 Protein ID WP_004199851.1
Coordinates 2740522..2741844 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QJR22_RS14980 Protein ID WP_002904790.1
Coordinates 2741844..2742110 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR22_RS14960 (QJR22_14965) 2735587..2738088 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
QJR22_RS14965 (QJR22_14970) 2738076..2739080 + 1005 WP_004199852.1 fimbrial protein -
QJR22_RS14970 (QJR22_14975) 2739213..2740505 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QJR22_RS14975 (QJR22_14980) 2740522..2741844 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
QJR22_RS14980 (QJR22_14985) 2741844..2742110 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QJR22_RS14985 (QJR22_14990) 2742376..2742702 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QJR22_RS14990 (QJR22_14995) 2742699..2743199 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QJR22_RS14995 (QJR22_15000) 2743177..2744556 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
QJR22_RS15000 (QJR22_15005) 2744902..2746056 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QJR22_RS15005 (QJR22_15010) 2746037..2746960 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T282073 WP_004199851.1 NZ_CP125349:c2741844-2740522 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT282073 WP_002904790.1 NZ_CP125349:c2742110-2741844 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References