Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 880494..881148 | Replicon | chromosome |
Accession | NZ_CP125349 | ||
Organism | Klebsiella pneumoniae strain WYKP594 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | R4YHX2 |
Locus tag | QJR22_RS05805 | Protein ID | WP_004144731.1 |
Coordinates | 880741..881148 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | QJR22_RS05800 | Protein ID | WP_002916312.1 |
Coordinates | 880494..880760 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QJR22_RS05775 (QJR22_05780) | 875650..877083 | - | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
QJR22_RS05780 (QJR22_05785) | 877202..877930 | - | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
QJR22_RS05785 (QJR22_05790) | 877980..878291 | + | 312 | WP_002916319.1 | N(4)-acetylcytidine aminohydrolase | - |
QJR22_RS05790 (QJR22_05795) | 878455..879114 | + | 660 | WP_002916317.1 | hemolysin III family protein | - |
QJR22_RS05795 (QJR22_05800) | 879265..880248 | - | 984 | WP_002916313.1 | tRNA-modifying protein YgfZ | - |
QJR22_RS05800 (QJR22_05805) | 880494..880760 | + | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
QJR22_RS05805 (QJR22_05810) | 880741..881148 | + | 408 | WP_004144731.1 | protein YgfX | Toxin |
QJR22_RS05810 (QJR22_05815) | 881155..881676 | - | 522 | WP_002916308.1 | flavodoxin FldB | - |
QJR22_RS05815 (QJR22_05820) | 881777..882673 | + | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
QJR22_RS05820 (QJR22_05825) | 882696..883409 | + | 714 | WP_002916301.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
QJR22_RS05825 (QJR22_05830) | 883415..885148 | + | 1734 | WP_004151783.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15936.69 Da Isoelectric Point: 11.4778
>T282068 WP_004144731.1 NZ_CP125349:880741-881148 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 408 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A378E4P6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |