Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880494..881148 Replicon chromosome
Accession NZ_CP125349
Organism Klebsiella pneumoniae strain WYKP594

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag QJR22_RS05805 Protein ID WP_004144731.1
Coordinates 880741..881148 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QJR22_RS05800 Protein ID WP_002916312.1
Coordinates 880494..880760 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR22_RS05775 (QJR22_05780) 875650..877083 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QJR22_RS05780 (QJR22_05785) 877202..877930 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QJR22_RS05785 (QJR22_05790) 877980..878291 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
QJR22_RS05790 (QJR22_05795) 878455..879114 + 660 WP_002916317.1 hemolysin III family protein -
QJR22_RS05795 (QJR22_05800) 879265..880248 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QJR22_RS05800 (QJR22_05805) 880494..880760 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QJR22_RS05805 (QJR22_05810) 880741..881148 + 408 WP_004144731.1 protein YgfX Toxin
QJR22_RS05810 (QJR22_05815) 881155..881676 - 522 WP_002916308.1 flavodoxin FldB -
QJR22_RS05815 (QJR22_05820) 881777..882673 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QJR22_RS05820 (QJR22_05825) 882696..883409 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJR22_RS05825 (QJR22_05830) 883415..885148 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T282068 WP_004144731.1 NZ_CP125349:880741-881148 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT282068 WP_002916312.1 NZ_CP125349:880494-880760 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References