Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 5182..5825 Replicon plasmid pWYKP594-3
Accession NZ_CP125347
Organism Klebsiella pneumoniae strain WYKP594

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag QJR22_RS00425 Protein ID WP_001044770.1
Coordinates 5182..5598 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag QJR22_RS00430 Protein ID WP_001261282.1
Coordinates 5595..5825 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR22_RS00405 (QJR22_00405) 1285..1557 - 273 Protein_1 transposase -
QJR22_RS00415 (QJR22_00415) 2539..3561 - 1023 WP_000361404.1 helicase UvrD -
QJR22_RS00420 (QJR22_00420) 3546..5108 - 1563 WP_004206609.1 AAA family ATPase -
QJR22_RS00425 (QJR22_00425) 5182..5598 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
QJR22_RS00430 (QJR22_00430) 5595..5825 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJR22_RS00435 (QJR22_00435) 5782..6243 + 462 WP_014343465.1 hypothetical protein -
QJR22_RS00440 (QJR22_00440) 6404..7348 + 945 WP_011977810.1 hypothetical protein -
QJR22_RS00445 (QJR22_00445) 7385..7777 + 393 WP_011977811.1 hypothetical protein -
QJR22_RS00450 (QJR22_00450) 7835..8356 + 522 WP_013214008.1 hypothetical protein -
QJR22_RS00455 (QJR22_00455) 8402..8605 + 204 WP_011977813.1 hypothetical protein -
QJR22_RS00460 (QJR22_00460) 8635..9639 + 1005 WP_011977814.1 hypothetical protein -
QJR22_RS00465 (QJR22_00465) 9823..10602 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-2 - 1..73344 73344


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T282063 WP_001044770.1 NZ_CP125347:c5598-5182 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT282063 WP_001261282.1 NZ_CP125347:c5825-5595 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References