Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5063961..5065642 Replicon chromosome
Accession NZ_CP125343
Organism Klebsiella pneumoniae strain WYKP589

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag QJR23_RS26500 Protein ID WP_002885155.1
Coordinates 5063961..5064878 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag QJR23_RS26505 Protein ID WP_004151732.1
Coordinates 5064884..5065642 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR23_RS26480 (QJR23_26480) 5059267..5060787 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
QJR23_RS26485 (QJR23_26485) 5060784..5061782 + 999 WP_002885172.1 ribose ABC transporter permease -
QJR23_RS26490 (QJR23_26490) 5061813..5062754 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
QJR23_RS26495 (QJR23_26495) 5062829..5063836 + 1008 WP_004151731.1 carbohydrate kinase family protein -
QJR23_RS26500 (QJR23_26500) 5063961..5064878 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QJR23_RS26505 (QJR23_26505) 5064884..5065642 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
QJR23_RS26510 (QJR23_26510) 5065728..5066456 - 729 WP_002885152.1 response regulator transcription factor -
QJR23_RS26515 (QJR23_26515) 5066729..5068876 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
QJR23_RS26520 (QJR23_26520) 5069106..5069792 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T282050 WP_002885155.1 NZ_CP125343:c5064878-5063961 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT282050 WP_004151732.1 NZ_CP125343:c5065642-5064884 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References