Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4907777..4908293 Replicon chromosome
Accession NZ_CP125343
Organism Klebsiella pneumoniae strain WYKP589

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QJR23_RS25700 Protein ID WP_002886902.1
Coordinates 4907777..4908061 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QJR23_RS25705 Protein ID WP_002886901.1
Coordinates 4908051..4908293 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR23_RS25675 (QJR23_25675) 4903261..4903524 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QJR23_RS25680 (QJR23_25680) 4903654..4903827 + 174 WP_002886906.1 hypothetical protein -
QJR23_RS25685 (QJR23_25685) 4903830..4904573 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QJR23_RS25690 (QJR23_25690) 4904930..4907068 + 2139 WP_217289782.1 anaerobic ribonucleoside-triphosphate reductase -
QJR23_RS25695 (QJR23_25695) 4907309..4907773 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QJR23_RS25700 (QJR23_25700) 4907777..4908061 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJR23_RS25705 (QJR23_25705) 4908051..4908293 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QJR23_RS25710 (QJR23_25710) 4908371..4910281 - 1911 WP_004152270.1 PRD domain-containing protein -
QJR23_RS25715 (QJR23_25715) 4910304..4911458 - 1155 WP_002886900.1 lactonase family protein -
QJR23_RS25720 (QJR23_25720) 4911524..4912264 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T282049 WP_002886902.1 NZ_CP125343:c4908061-4907777 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT282049 WP_002886901.1 NZ_CP125343:c4908293-4908051 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References