Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4804484..4805294 Replicon chromosome
Accession NZ_CP125343
Organism Klebsiella pneumoniae strain WYKP589

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag QJR23_RS25205 Protein ID WP_002887280.1
Coordinates 4804484..4805017 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QJR23_RS25210 Protein ID WP_002887278.1
Coordinates 4805028..4805294 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR23_RS25200 (QJR23_25200) 4803315..4804436 + 1122 WP_002887282.1 cupin domain-containing protein -
QJR23_RS25205 (QJR23_25205) 4804484..4805017 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
QJR23_RS25210 (QJR23_25210) 4805028..4805294 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QJR23_RS25215 (QJR23_25215) 4805397..4806830 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
QJR23_RS25220 (QJR23_25220) 4806820..4807503 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
QJR23_RS25225 (QJR23_25225) 4807675..4809060 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
QJR23_RS25230 (QJR23_25230) 4809078..4809422 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T282048 WP_002887280.1 NZ_CP125343:c4805017-4804484 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT282048 WP_002887278.1 NZ_CP125343:c4805294-4805028 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References