Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2739481..2741069 Replicon chromosome
Accession NZ_CP125343
Organism Klebsiella pneumoniae strain WYKP589

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag QJR23_RS14955 Protein ID WP_004199851.1
Coordinates 2739481..2740803 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QJR23_RS14960 Protein ID WP_002904790.1
Coordinates 2740803..2741069 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR23_RS14940 (QJR23_14940) 2734546..2737047 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
QJR23_RS14945 (QJR23_14945) 2737035..2738039 + 1005 WP_004199852.1 fimbrial protein -
QJR23_RS14950 (QJR23_14950) 2738172..2739464 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QJR23_RS14955 (QJR23_14955) 2739481..2740803 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
QJR23_RS14960 (QJR23_14960) 2740803..2741069 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QJR23_RS14965 (QJR23_14965) 2741335..2741661 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QJR23_RS14970 (QJR23_14970) 2741658..2742158 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QJR23_RS14975 (QJR23_14975) 2742136..2743515 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
QJR23_RS14980 (QJR23_14980) 2743861..2745015 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QJR23_RS14985 (QJR23_14985) 2744996..2745919 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T282046 WP_004199851.1 NZ_CP125343:c2740803-2739481 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT282046 WP_002904790.1 NZ_CP125343:c2741069-2740803 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References