Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880526..881180 Replicon chromosome
Accession NZ_CP125343
Organism Klebsiella pneumoniae strain WYKP589

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag QJR23_RS05795 Protein ID WP_004144731.1
Coordinates 880773..881180 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QJR23_RS05790 Protein ID WP_002916312.1
Coordinates 880526..880792 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR23_RS05765 (QJR23_05765) 875682..877115 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QJR23_RS05770 (QJR23_05770) 877234..877962 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QJR23_RS05775 (QJR23_05775) 878012..878323 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
QJR23_RS05780 (QJR23_05780) 878487..879146 + 660 WP_002916317.1 hemolysin III family protein -
QJR23_RS05785 (QJR23_05785) 879297..880280 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QJR23_RS05790 (QJR23_05790) 880526..880792 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QJR23_RS05795 (QJR23_05795) 880773..881180 + 408 WP_004144731.1 protein YgfX Toxin
QJR23_RS05800 (QJR23_05800) 881187..881708 - 522 WP_002916308.1 flavodoxin FldB -
QJR23_RS05805 (QJR23_05805) 881809..882705 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QJR23_RS05810 (QJR23_05810) 882728..883441 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJR23_RS05815 (QJR23_05815) 883447..885180 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T282041 WP_004144731.1 NZ_CP125343:880773-881180 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT282041 WP_002916312.1 NZ_CP125343:880526-880792 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References