Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799485..800142 Replicon chromosome
Accession NC_018522
Organism Klebsiella pneumoniae subsp. pneumoniae 1084

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag A79E_RS04025 Protein ID WP_002916310.1
Coordinates 799732..800142 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag A79E_RS04020 Protein ID WP_002916312.1
Coordinates 799485..799751 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A79E_RS03995 794693..796126 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
A79E_RS04000 796245..796973 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
A79E_RS04005 797023..797334 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
A79E_RS04010 797498..798157 + 660 WP_002916317.1 hemolysin III family protein -
A79E_RS04015 798256..799239 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
A79E_RS04020 799485..799751 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
A79E_RS04025 799732..800142 + 411 WP_002916310.1 protein YgfX Toxin
A79E_RS04030 800149..800670 - 522 WP_002916308.1 flavodoxin FldB -
A79E_RS04035 800771..801667 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
A79E_RS04040 801690..802403 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A79E_RS04045 802409..804142 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T28203 WP_002916310.1 NC_018522:799732-800142 [Klebsiella pneumoniae subsp. pneumoniae 1084]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T28203 NC_018522:799732-800142 [Klebsiella pneumoniae subsp. pneumoniae 1084]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT28203 WP_002916312.1 NC_018522:799485-799751 [Klebsiella pneumoniae subsp. pneumoniae 1084]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT28203 NC_018522:799485-799751 [Klebsiella pneumoniae subsp. pneumoniae 1084]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References