Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2093..2673 Replicon plasmid pWYKP589-4
Accession NZ_CP125340
Organism Klebsiella pneumoniae strain WYKP589

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag QJR23_RS00080 Protein ID WP_071177730.1
Coordinates 2093..2407 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag QJR23_RS00085 Protein ID WP_000093040.1
Coordinates 2395..2673 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR23_RS00060 (QJR23_00060) 1..732 + 732 WP_071177728.1 MobC family replication-relaxation protein -
QJR23_RS00065 (QJR23_00065) 739..1269 + 531 WP_071177729.1 hypothetical protein -
QJR23_RS00070 (QJR23_00070) 1296..1475 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
QJR23_RS00075 (QJR23_00075) 1501..1929 - 429 WP_001140599.1 hypothetical protein -
QJR23_RS00080 (QJR23_00080) 2093..2407 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJR23_RS00085 (QJR23_00085) 2395..2673 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
QJR23_RS00090 (QJR23_00090) 2848..3213 - 366 WP_072354022.1 TonB family protein -
QJR23_RS00095 (QJR23_00095) 3210..3581 - 372 WP_001237044.1 cell envelope integrity protein TolA -
QJR23_RS00100 (QJR23_00100) 3855..4100 - 246 WP_032440458.1 hypothetical protein -
QJR23_RS00105 (QJR23_00105) 4745..6232 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T282029 WP_071177730.1 NZ_CP125340:c2407-2093 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT282029 WP_000093040.1 NZ_CP125340:c2673-2395 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References