Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 466..940 Replicon plasmid pWYKP589-5
Accession NZ_CP125339
Organism Klebsiella pneumoniae strain WYKP589

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag QJR23_RS00010 Protein ID WP_004197762.1
Coordinates 466..732 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag QJR23_RS00015 Protein ID WP_000879771.1
Coordinates 716..940 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR23_RS00005 (QJR23_00005) 46..396 + 351 WP_004197756.1 hypothetical protein -
QJR23_RS00010 (QJR23_00010) 466..732 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJR23_RS00015 (QJR23_00015) 716..940 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
QJR23_RS00020 (QJR23_00020) 1607..1819 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
QJR23_RS00025 (QJR23_00025) 1826..2335 - 510 WP_032433972.1 MbeB family mobilization protein -
QJR23_RS00030 (QJR23_00030) 2370..2804 - 435 Protein_5 relaxase/mobilization nuclease domain-containing protein -
QJR23_RS00035 (QJR23_00035) 3013..3357 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
QJR23_RS00040 (QJR23_00040) 3347..3523 - 177 WP_004197757.1 hypothetical protein -
QJR23_RS00045 (QJR23_00045) 4679..5005 + 327 WP_050516389.1 hypothetical protein -
QJR23_RS00050 (QJR23_00050) 5031..5576 + 546 WP_023317533.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T282028 WP_004197762.1 NZ_CP125339:c732-466 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT282028 WP_000879771.1 NZ_CP125339:c940-716 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References