Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4057..4637 Replicon plasmid pWYKP586-3
Accession NZ_CP125337
Organism Klebsiella pneumoniae strain WYKP586

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag QJR21_RS29430 Protein ID WP_071177730.1
Coordinates 4057..4371 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag QJR21_RS29435 Protein ID WP_000093040.1
Coordinates 4359..4637 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR21_RS29405 (QJR21_29405) 1..1965 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
QJR21_RS29410 (QJR21_29410) 1965..2696 + 732 WP_071177728.1 MobC family replication-relaxation protein -
QJR21_RS29415 (QJR21_29415) 2703..3233 + 531 WP_071177729.1 hypothetical protein -
QJR21_RS29420 (QJR21_29420) 3260..3439 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
QJR21_RS29425 (QJR21_29425) 3465..3893 - 429 WP_001140599.1 hypothetical protein -
QJR21_RS29430 (QJR21_29430) 4057..4371 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJR21_RS29435 (QJR21_29435) 4359..4637 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
QJR21_RS29440 (QJR21_29440) 4812..5177 - 366 WP_072354022.1 TonB family protein -
QJR21_RS29445 (QJR21_29445) 5174..5545 - 372 WP_001237044.1 cell envelope integrity protein TolA -
QJR21_RS29450 (QJR21_29450) 5819..6064 - 246 WP_032440458.1 hypothetical protein -
QJR21_RS29455 (QJR21_29455) 6709..8196 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T282027 WP_071177730.1 NZ_CP125337:c4371-4057 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT282027 WP_000093040.1 NZ_CP125337:c4637-4359 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References